Home :: Selective Androgen Receptor Modulators :: Buy Liquid GW-1516 30ml 20mg/ml (In Stock)

Buy Liquid GW-1516 30ml 20mg/ml (In Stock)

Buy Liquid GW-1516 30ml 20mg/ml (In Stock)

Buy Liquid GW-1516 30ml 20mg/ml (In Stock)

Liquid GW-1516 30ml 20mg/ml

GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ.
 
In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure. Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1
61%
SKU SKU17681
 
Market price: $89.99
Our price: $34.99 (26.24)
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